Biotechnology and clinical application. 4. Monoclonal antibody for cancer.
نویسندگان
چکیده
منابع مشابه
Rabbit monoclonal antibody: potential application in cancer therapy.
By targeting antigens specifically, monoclonal antibodies represent a new class of therapeutic agents for the clinical management of various diseases including cancers. Monoclonal antibody technology has been greatly developed by reducing murine content in antibodies to minimize side effects in clinical applications. However, several intrinsic disadvantages of antibodies with murine origin limi...
متن کاملDevelopment and Application of an Immunocapture PCR Diagnostic Assay Based on the Monoclonal Antibody for the Detection of Shigella
Background: Shigella is among the most important human pathogenic microorganisms, infecting both humans and nonhuman and causing clinically severe diarrhea. Shigella must be enriched before detection, which is time-consuming.Objectives: To develop a sensitive, rapid, and specifc method for Shigella detection.Materials and Methods: S...
متن کاملDevelopment of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy.
Most malignant tumors are derived from epithelium, and claudin (CLDN)-3 and CLDN-4 are frequently overexpressed in such tumors. Although antibodies have potential in cancer diagnostics and therapy, development of antibodies against CLDNs has been difficult because the extracellular domains of CLDNs are too small and there is high homology among human, rat, and mouse sequences. Here, we created ...
متن کاملPreparation of Mouse Monoclonal Antibody for RB1CC1 and Its Clinical Application
RB1-inducible coiled-coil 1 (RB1CC1; also known as FIP200) plays important roles in several biological pathways such as cell proliferation and autophagy. Evaluation of RB1CC1 expression can provide useful clinical information on various cancers and neurodegenerative diseases. In order to realize the clinical applications, it is necessary to establish a stable supply of antibody and reproducible...
متن کاملTitle : Development of an anti - claudin - 3 and - 4 bispecific monoclonal antibody for cancer
Affiliations: Laboratory of Bio-Functional Molecular Chemistry (X.L., M.I., A.W., Y.Ka., Y.Ki., K.Y., M.K.) and Laboratory of Analytical Chemistry (T.Y., T.U.), Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo 158-0098, Japan (M.T., A.I.) Department of Biochemistry a...
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ژورنال
عنوان ژورنال: Ensho
سال: 1986
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.6.233